In a pre-clinical study
HYMOVIS® improved lubrication and demonstrated superior friction reduction compared with other commercially available HA products1,a
Effects of HA on cartilage friction reduction at various speeds1
aPreclinical test data may not be indicative of human clinical outcomes.
bThe HA in TRILURON® is the same chemical formulation as the HA in HYALGAN®.
Third-party trademarks used herein are trademarks of their respective owners.
Study design: Bovine articular cartilage was pressed against polished glass while bathed in commercially available HA products. While pressed, the cartilage was slid at predetermined speeds (0.1 mm/sec to 10 mm/sec) to represent the sliding speeds of a possible range of daily activities. During sliding, both compression and friction forces were measured to calculate the friction coefficient.
Friction reduction was seen across a wide range of sliding speeds that may represent a possible range of daily activities1
In a pre-clinical study
HYMOVIS® demonstrated greater recovery of structure and elasticity under repeated mechanical stress2,a
Comparison of HYMOVIS® with chemically cross-linked, higher-molecular weight HAs2
All 3 HAs started at a pre-stress baseline of 100% and had an instantaneous post-stress response of 29%.a
Following repeated stress, the structure of HYMOVIS® stabilizes due to the reversible hydrophobic interactions of the amide-containing alkyl side chains.a
aPreclinical test data may not be indicative of human clinical outcomes.
Third-party trademarks used herein are trademarks of their respective owners.
Study design: Recovery of mechanical properties after a shock was investigated as a function of time by oscillatory measurement after destruction of the gel network for each product: HYMOVIS®, Synvisc®, and Durolane®. The stress cycle was repeated 6 times.
Comparison of HYMOVIS® with chemically cross-linked, higher-molecular weight HAs2
All 3 HAs started at a pre-stress baseline of 100% and had an instantaneous post-stress response of 29%.a
Following repeated stress, the structure of HYMOVIS® stabilizes due to the reversible hydrophobic interactions of the amide-containing alkyl side chains.a
aPreclinical test data may not be indicative of human clinical outcomes.
Third-party trademarks used herein are trademarks of their respective owners.
Study design: Recovery of mechanical properties after a shock was investigated as a function of time by oscillatory measurement after destruction of the gel network for each product: HYMOVIS®, Synvisc®, and Durolane®. The stress cycle was repeated 6 times.