In a pre-clinical study
HYMOVIS® improved lubrication and demonstrated superior friction reduction compared with other commercially available HA products1,a
Effects of HA on cartilage friction reduction at various speeds1
![Line graph of HA effects of friction reduction on cartilage at carious sliding speeds](https://hcp.hymovis.com/wp-content/uploads/sites/2/2021/01/HYM_HymovisBonnevieStudy.png)
aPreclinical test data may not be indicative of human clinical outcomes.
bThe HA in TRILURON® is the same chemical formulation as the HA in HYALGAN®.
Third-party trademarks used herein are trademarks of their respective owners.
Study design: Bovine articular cartilage was pressed against polished glass while bathed in commercially available HA products. While pressed, the cartilage was slid at predetermined speeds (0.1 mm/sec to 10 mm/sec) to represent the sliding speeds of a possible range of daily activities. During sliding, both compression and friction forces were measured to calculate the friction coefficient.
Friction reduction was seen across a wide range of sliding speeds that may represent a possible range of daily activities1
In a pre-clinical study
HYMOVIS® demonstrated greater recovery of structure and elasticity under repeated mechanical stress2,a
Comparison of HYMOVIS® with chemically cross-linked, higher-molecular weight HAs2
All 3 HAs started at a pre-stress baseline of 100% and had an instantaneous post-stress response of 29%.a
Following repeated stress, the structure of HYMOVIS® stabilizes due to the reversible hydrophobic interactions of the amide-containing alkyl side chains.a
aPreclinical test data may not be indicative of human clinical outcomes.
Third-party trademarks used herein are trademarks of their respective owners.
Study design: Recovery of mechanical properties after a shock was investigated as a function of time by oscillatory measurement after destruction of the gel network for each product: HYMOVIS®, Synvisc®, and Durolane®. The stress cycle was repeated 6 times.
Comparison of HYMOVIS® with chemically cross-linked, higher-molecular weight HAs2
All 3 HAs started at a pre-stress baseline of 100% and had an instantaneous post-stress response of 29%.a
Following repeated stress, the structure of HYMOVIS® stabilizes due to the reversible hydrophobic interactions of the amide-containing alkyl side chains.a
aPreclinical test data may not be indicative of human clinical outcomes.
Third-party trademarks used herein are trademarks of their respective owners.
Study design: Recovery of mechanical properties after a shock was investigated as a function of time by oscillatory measurement after destruction of the gel network for each product: HYMOVIS®, Synvisc®, and Durolane®. The stress cycle was repeated 6 times.